Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Orbitofrontal cortex neurons: role in olfactory and visual association learning

E T Rolls1, H D Critchley, R Mason

  • 1University of Oxford, Department of Experimental Psychology, United Kingdom.

Journal of Neurophysiology
|May 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mercury transfer and transformation from mine soil to river sediments: the potential role of amorphous iron oxides in methylation processes in southern Burkina Faso.

Environmental science. Processes & impacts·2025
Same author

Having the Heart to Exercise Control: Cardiac Interoception Influences Self-Paced Exercise Regulation.

European journal of sport science·2025
Same author

Can the neural representation of physical pain predict empathy for pain in others?

Social cognitive and affective neuroscience·2024
Same author

Characterizing the multi-dimensional reaction dynamics of dihalomethanes using XUV-induced Coulomb explosion imaging.

The Journal of chemical physics·2023
Same author

Appreciating the links between heart failure and depression.

QJM : monthly journal of the Association of Physicians·2023
Same author

Efficacy of immune checkpoint inhibitors for the treatment of advanced melanoma in patients with concomitant chronic lymphocytic leukemia.

Annals of oncology : official journal of the European Society for Medical Oncology·2023
Same journal

Comprehensive Analysis of Auditory Nerve Fiber Responses using Fiber-Specific Modeling.

Journal of neurophysiology·2026
Same journal

HCN channels modulate the medium afterhyperpolarization and adjust the firing gain of fast alpha motoneurons in mice.

Journal of neurophysiology·2026
Same journal

Targeting intracranial electrical stimulation to network regions defined within individuals causes network-level effects.

Journal of neurophysiology·2026
Same journal

When "Noise" Isn't Simply Noise: Deterministic Postural Drive During Noisy Galvanic Vestibular Stimulation (nGVS).

Journal of neurophysiology·2026
Same journal

Abrupt Scene Onsets and Gradually Emerging Scene Information Produce Distinct EEG Decoding Dynamics.

Journal of neurophysiology·2026
Same journal

From discovery to translation: charting a course for the <i>Journal of Neurophysiology</i>.

Journal of neurophysiology·2026
See all related articles

Orbitofrontal cortex neurons learn odor-taste associations, but olfactory responses are less flexible than visual ones. This suggests stable flavor perception relies on slower olfactory learning in the orbitofrontal cortex.

Area of Science:

  • Neuroscience
  • Sensory processing
  • Learning and memory

Background:

  • The orbitofrontal cortex (OFC) integrates sensory information, including taste, olfaction, and vision.
  • It plays a crucial role in learning associations between stimuli and rewards, vital for motivated behaviors like feeding.

Purpose of the Study:

  • To investigate the neuronal mechanisms of odor-taste association formation and reversal in the OFC.
  • To compare the flexibility of olfactory versus visual neuronal responses to taste-reward changes.

Main Methods:

  • Electrophysiological recordings were made from olfactory neurons in the OFC of macaques.
  • Neurons were monitored during an olfactory discrimination task and its subsequent reversal.
  • Visually responsive OFC neurons were also tested during a visual discrimination reversal task for comparison.

Related Experiment Videos

Main Results:

  • 68% of odor-responsive OFC neurons altered their responses following changes in odor-taste reward associations.
  • 25% of these neurons showed full response reversal, and 43% showed extinction of differential responses.
  • In contrast, 71% of visually responsive OFC neurons rapidly reversed their responses during a visual-taste reversal task.

Conclusions:

  • OFC olfactory neurons modify responses based on associated tastes, contributing to the motivational value of odors.
  • Olfactory responses in the OFC are less flexible and slower to change compared to visual responses.
  • This relative inflexibility supports the stability of odor-taste associations, crucial for flavor perception.