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Single dose pharmacokinetics of medetomidine in sheep
D K Muge1, J P Chambers, A Livingston
1Department of Veterinary Pre-clinical Sciences, University of Liverpool, South Wirral, Cheshire, UK.
Abstract:
The pharmacokinetics of medetomidine hydrochloride (Domitor) administered at a single dose of 15 micrograms/kg i.v. in sheep are described. Plasma medetomidine concentrations were determined using a sensitive radioreceptor assay technique, capable of also measuring metabolites which would bind to alpha 2 adrenergic receptors. Medetomidine was rapidly distributed, with a half-life of distribution of 4.65 +/- 0.65 min. The apparent volume of distribution was 2.69 +/- 0.62 L/kg, while elimination half-life was 37.85 +/- 2.84 min. Total body clearance varied between 16.29 and 151.81 mL/min.kg. Pharmacological effects of medetomidine paralleled its plasma concentration.