Protein targeting to the plant vacuole--a historical perspective

Although many properties of the targeting of plant endomembrane proteins are similar to mammalian and yeast systems, several clear differences are found that will be stressed in this review. In the past few years, we have seen an advancement in our understanding of the signals for vacuolar protein targeting and some insights into the mechanisms of transport to the vacuole in the plant cell. This work will form the basis for elucidation of the fundamental principles that govern protein trafficking through the secretory system to the vacuole.