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Immunogenicity of random polymers of l-glutamic acid, l-alanine and l-tyrosine in inbred hamsters
The random terpolymer GAT has been found to be immunogenic in hamsters whereas the random copolymers GA or GT were found to be nonimmunogenic. Although no immune responses to GA or GT could be elicited, the anti-GAT antibody response contained populations inhibited specifically by GA, GT and poly-G. These data suggest that in hamsters, recognition of GAT occurs via determinants which are not present in GA or GT.
The random terpolymer GAT has been found to be immunogenic in hamsters whereas the random copolymers GA or GT were found to be nonimmunogenic. Although no immune responses to GA or GT could be elicited, the anti-GAT antibody response contained populations inhibited specifically by GA, GT and poly-G. These data suggest that in hamsters, recognition of GAT occurs via determinants which are not present in GA or GT.