Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peripheral glucose metabolism in human hyperprolactinaemia

M C Foss1, F J Paula, G M Paccola

  • 1Department of Medicine, São Paulo University, Brazil.

Clinical Endocrinology
|December 1, 1995
PubMed
Summary

Hyperprolactinaemia in humans is linked to insulin resistance, despite normal muscle glucose uptake. This condition shows higher insulin levels and impaired free fatty acid suppression after glucose intake, indicating metabolic dysfunction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aliskiren effect on non-alcoholic steatohepatitis in metabolic syndrome.

Diabetology & metabolic syndrome·2017
Same author

Transcriptome meta-analysis of peripheral lymphomononuclear cells indicates that gestational diabetes is closer to type 1 diabetes than to type 2 diabetes mellitus.

Molecular biology reports·2013
Same author

Testicular function in patients with type 1 diabetes treated with high-dose CY and autologous hematopoietic SCT.

Bone marrow transplantation·2011
Same author

Predictors of restenosis after percutaneous coronary intervention using bare-metal stents: a comparison between patients with and without dysglycemia.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2010
Same author

Use of alprostadil, a stable prostaglandin E1 analogue, for the attenuation of rat skeletal muscle ischemia and reperfusion injury.

Minerva chirurgica·2009
Same author

Mineralocorticoid receptor p.I180V polymorphism: association with body mass index and LDL-cholesterol levels.

Journal of endocrinological investigation·2009

Area of Science:

  • Endocrinology
  • Metabolic Research

Background:

  • Human prolactin (PRL) is primarily known for mammotrophic effects.
  • Its role in metabolic control, unlike in other species, remains largely uncharacterized.
  • This study investigates PRL's impact on peripheral glucose metabolism.

Purpose of the Study:

  • To evaluate the effect of hyperprolactinaemia on peripheral muscle glucose metabolism.
  • To assess glucose uptake and utilization in hyperprolactinaemic individuals.

Main Methods:

  • Forearm technique combined with indirect calorimetry to measure glucose metabolism.
  • Analysis of forearm muscle glucose uptake, oxidative, and non-oxidative utilization.
  • Measurement of serum glucose, insulin, and free fatty acids (FFA) post-glucose ingestion.

Related Experiment Videos

Main Results:

  • No significant differences in forearm muscle glucose uptake or utilization between hyperprolactinaemic and normal subjects.
  • Significantly higher serum insulin levels in hyperprolactinaemic patients post-glucose.
  • Reduced suppression of serum FFA levels in hyperprolactinaemic patients, suggesting impaired insulin antilipolytic effect.

Conclusions:

  • Spontaneous hyperprolactinaemia is associated with insulin resistance in humans.
  • Hyperinsulinaemia in hyperprolactinaemia does not proportionally increase forearm glucose uptake.
  • Impaired insulin antilipolytic effect on FFA suppression is observed in hyperprolactinaemia.