Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ectopic extramammary Paget's disease affecting the upper abdomen

Y Onishi1, K Ohara

  • 1Department of Dermatology, Toranomon Hospital, Tokyo, Japan.

The British Journal of Dermatology
|May 1, 1996
PubMed
Summary

Ectopic extramammary Paget's disease (EMPD) is rare, with only 12 reported cases. This study found ectopic EMPD clinically and histologically indistinguishable from ordinary EMPD, suggesting a shared origin.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Problem of molecular psychiatry in view of the trinucleotide repeat expansion disease].

Nihon rinsho. Japanese journal of clinical medicine·1999
Same author

Schizophrenia and the serotonin-2A receptor promoter polymorphism.

Psychiatry research·1999
Same author

Correlation between symptomatic, radiological and etiological diagnosis in acute ischemic stroke.

Acta neurologica Scandinavica·1999
Same author

Apolipoprotein E epsilon 4 allele and Japanese late-onset depressive disorders.

Biological psychiatry·1999
Same author

Ultrasound biomicroscopy of ciliary body cysts.

American journal of ophthalmology·1999
Same author

Use of daily low-dose carboplatin in radiotherapy for non-small cell lung cancer.

Anticancer research·1999

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Extramammary Paget's disease (EMPD) is a rare intraepithelial adenocarcinoma.
  • Ectopic EMPD, occurring outside typical genital/perianal regions, is exceptionally uncommon.

Observation:

  • A 57-year-old male presented with upper abdominal lesions initially suspected as Bowen's disease or basal cell epithelioma.
  • Histopathological examination confirmed ectopic extramammary Paget's disease (EMPD).
  • This represents the first ectopic EMPD case in a 20-year experience with 129 EMPD cases (0.78% frequency).

Findings:

  • Only 12 cases of ectopic EMPD have been reported globally, including this case.
  • Demographic data (male/female ratio, mean age) for ectopic EMPD align closely with ordinary EMPD.

Related Experiment Videos

  • Clinical and histological features of ectopic EMPD show no significant differences compared to ordinary EMPD.

    • Implications:

    • Ectopic and ordinary EMPD are likely the same disease entity, sharing similar origins and pathogenesis.
    • The hypothesis that Paget's cells arise from pluripotential germinative cells is supported.
    • Further research into the origins of EMPD is warranted to understand its development in ectopic locations.