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HLA antigens and asthma in Greeks
J Apostolakis1, M Toumbis, K Konstantopoulos
1First University Department of Medicine, Laikon General Hospital, Athens, Greece.
Respiratory Medicine
|April 1, 1996
Summary
This study found that certain Human Leukocyte Antigen (HLA) B antigens are less common in Greek asthma patients. Different HLA antigen frequencies were observed in adult and child asthma groups, suggesting a role for immunogenetics in asthma.
Area of Science:
- Immunogenetics
- Allergy and Immunology
- Respiratory Medicine
Background:
- Asthma is a complex respiratory disease with suspected immunogenetic components.
- Human Leukocyte Antigen (HLA) genes play a crucial role in immune responses.
- Previous research suggests associations between specific HLA types and various diseases.
Purpose of the Study:
- To investigate the frequencies of HLA-A and HLA-B antigens in Greek asthmatic patients.
- To compare HLA antigen profiles between asthmatic children and adults.
- To explore the potential role of specific HLA antigens in asthma pathogenesis.
Main Methods:
- Determined HLA-A and HLA-B antigen profiles in 76 Greek asthmatic patients (35 children, 41 adults).
- Compared patient HLA antigen frequencies to 400 healthy unrelated controls from the same population.
- Utilized the standard National Institutes of Health (NIH) lymphocytotoxicity test for HLA typing.
Main Results:
- Overall, asthmatic patients showed a statistically significant lower frequency of HLA-B5 and HLA-B35 antigens compared to controls.
- Adult asthmatics exhibited an increased frequency of the HLA-B8 antigen.
- Asthmatic children displayed a significantly higher frequency of HLA-A10 and a lower frequency of HLA-B5.
Conclusions:
- Different HLA antigens may be implicated in the pathogenesis of various clinical forms of asthma.
- The study highlights the need for refined patient grouping criteria to better understand immunogenetic factors in asthma.
- Findings suggest distinct immunogenetic influences on childhood and adult-onset asthma.
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