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Calcium controls second-messenger signalling in olfactory cilia

I Boekhoff1, C Kroner, H Breer

  • 1University Stuttgart-Hohenheim, Institute of Zoophysiology, Stuttgart, Germany.

Cellular Signalling
|March 1, 1996
PubMed
Summary
This summary is machine-generated.

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Elevated intracellular calcium levels reduce olfactory neuron sensitivity by inhibiting adenylate cyclase, not by activating phosphodiesterases. This calcium-dependent mechanism dampens the odor-induced cyclic adenosine monophosphate (cAMP) response.

Area of Science:

  • Neuroscience
  • Olfactory receptor function
  • Cell signaling

Background:

  • Olfactory neurons exhibit decreased responsiveness after odorant stimulation.
  • Intracellular calcium concentration increases are implicated in this reduced sensitivity.

Purpose of the Study:

  • To investigate the mechanism by which calcium regulates olfactory neuron responsiveness.
  • To determine if calcium affects the olfactory signaling cascade.

Main Methods:

  • Dose-dependent analysis of calcium's effect on odor-induced cyclic adenosine monophosphate (cAMP) response in olfactory cilia.
  • Assessment of phosphodiesterase activity and adenylate cyclase inhibition by calcium.

Main Results:

  • Calcium significantly diminished the odor-induced cAMP response in a dose-dependent manner.

Related Experiment Videos

  • This attenuation was not caused by increased phosphodiesterase activity.
  • Calcium ions were found to inhibit adenylate cyclase activity.

    • Conclusions:

    • Calcium-dependent inhibition of adenylate cyclase is the primary mechanism for down-regulating olfactory neuron responsiveness.
    • This finding clarifies the role of calcium in olfactory signal processing and adaptation.