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Related Experiment Videos

Contraception with anti-progesterone

M L Swahn1, K G Danielsson, M Bygdeman

  • 1Department of Obstetrics & Gynaecology, Karolinska Hospital, Stockholm, Seden.

Bailliere'S Clinical Obstetrics and Gynaecology
|April 1, 1996
PubMed
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Anti-progesterones, like Mifepristone, show promise as contraceptives by preventing ovulation or altering the uterine lining. Research suggests potential for new low-dose formulations that do not affect ovarian function.

Area of Science:

  • Reproductive endocrinology
  • Pharmacology
  • Contraception development

Background:

  • Anti-progesterones offer contraceptive potential through mechanisms like ovulation inhibition or endometrial modification.
  • Mifepristone has demonstrated efficacy as a once-a-month contraceptive and in emergency post-coital contraception.

Purpose of the Study:

  • To explore the contraceptive potential of anti-progesterones, specifically Mifepristone.
  • To investigate the differential susceptibility of the endometrium versus the hypothalamic-pituitary axis to Mifepristone.
  • To assess the feasibility of developing novel low-dose Mifepristone contraceptive regimens.

Main Methods:

  • Clinical studies evaluating once-a-month Mifepristone in the early luteal phase.
  • Assessment of Mifepristone's efficacy for emergency post-coital contraception.
Keywords:
Abortifacient AgentsAbortion, Drug InducedAbortion, InducedBiologyContraceptionContraception ResearchEndocrine SystemEndometrial EffectsEndometriumFamily PlanningFertility Control, PostconceptionGenitaliaGenitalia, FemaleHormone AntagonistsHormonesLiterature ReviewOvarian EffectsOvaryPhysiologyRu-486--pharmacodynamicsUrogenital SystemUterus

Related Experiment Videos

  • Analysis of endometrial and hypothalamic-pituitary responses to Mifepristone.

    • Main Results:

    • Once-a-month Mifepristone is an effective contraceptive method.
    • Mifepristone is a highly effective emergency post-coital contraceptive.
    • The endometrium exhibits greater sensitivity to Mifepristone than the hypothalamic and pituitary regions.

    Conclusions:

    • Mifepristone is a viable option for monthly and emergency contraception.
    • Targeting endometrial sensitivity to Mifepristone may enable the development of novel contraceptive strategies.
    • Low-dose daily or weekly Mifepristone regimens could offer effective contraception without impacting ovarian function.