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Related Experiment Videos

Studies on powder plug formation using a simulated capsule filling machine

J R Britten1, M I Barnett, N A Armstrong

  • 1Parke-Davis Warner-Lambert, Pontypool, Gwent, UK.

The Journal of Pharmacy and Pharmacology
|March 1, 1996
PubMed
Summary
This summary is machine-generated.

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Pharmaceutical research·1995

Machine parameters significantly impact powder plug properties during capsule filling. Increased compression speed reduces plug weight, while higher pressures minimize weight variations, potentially affecting drug release.

Area of Science:

  • Pharmaceutical Technology
  • Powder Engineering
  • Drug Delivery Systems

Background:

  • Capsule filling machines are crucial for accurate pharmaceutical dosage forms.
  • Understanding powder plug properties is essential for consistent drug release and manufacturing.
  • The Macofar 13-2 is a common dosating-type capsule-filling machine.

Purpose of the Study:

  • To investigate how machine parameters affect powder plug weight and density.
  • To analyze the influence of compression and ejection speeds, and applied pressures.
  • To compare the behavior of different powder types (Starch 1500 and lubricated lactose).

Main Methods:

  • Simulated the Macofar 13-2 capsule-filling machine.
  • Varied machine parameters: piston ejection speed, compression speed, and applied pressure.

Related Experiment Videos

  • Measured powder plug weight and density.
  • Compared axial and radial pressures for Starch 1500 and lubricated lactose.

    • Main Results:

    • Piston ejection speed did not influence plug properties.
    • Increased compression speed resulted in less consolidated plugs and reduced weight.
    • Higher applied pressures minimized plug weight variations.
    • Significant differences in axial and radial pressures were observed between Starch 1500 and lubricated lactose.

    Conclusions:

    • Compression speed is a critical parameter affecting powder plug consolidation and weight.
    • Applied pressure influences plug weight consistency, with implications for drug release characteristics.
    • Material properties (consolidation and elastic) significantly dictate pressure generation in powder plugs.