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Effects of respiration on left ventricular diastolic function in healthy children

F K Alehan1, S Ozkutlu, D Alehan

  • 1Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.

European Heart Journal
|March 1, 1996
PubMed

Insights

Spontaneous breathing significantly alters left ventricular diastolic function in children. Key mitral valve filling parameters change with inspiration, necessitating standardized respiratory phase assessment for accurate clinical evaluation.

Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Physiology
  • Echocardiography

Background:

  • Left ventricular diastolic function is crucial for cardiac health.
  • Understanding normal variations in diastolic filling is essential for accurate diagnosis.
  • Spontaneous respiration can influence hemodynamic parameters.

Purpose of the Study:

  • To investigate the impact of spontaneous respiration on left ventricular diastolic filling patterns in healthy children.
  • To identify specific echocardiographic indices affected by respiratory phases.

Main Methods:

  • Pulsed Doppler echocardiography was used to measure mitral valve filling.
  • 20 healthy children aged 3 to 12.5 years were studied.
  • Analysis focused on variations in diastolic filling parameters during respiratory cycles.

Main Results:

  • Significant respiratory variations were observed in peak early filling velocity, early to late peak filling velocity ratio, and early to late diastolic velocity-time integral, all decreasing during inspiration.
  • Late peak filling velocity significantly increased during inspiration.
  • Other diastolic filling variables remained unchanged with respiratory phase.

Conclusions:

  • Spontaneous respiration causes significant, measurable changes in left ventricular diastolic filling in children.
  • Clinical assessment of pediatric diastolic function requires standardization to respiratory phases for reliable interpretation.

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