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HSP70-1 promoter region alleles and susceptibility to rheumatoid arthritis
S A Quadri1, V Taneja, N K Mehra
1Department of Pathology, McMaster University Medical Center, Hamilton, Ontario, Canada.
Clinical and Experimental Rheumatology
|March 1, 1996
Abstract:
The distribution of HSP70-1 promoter alleles was studied in 90 adult Caucasian RA patients (65 European and 25 Asian Indian) and 113 normal control (60 European and 53 Asian Indian). The HSP70-1 promoter alleles were defined by oligonucleotide typing of polymerase chain (PCR)-amplified genomic DNA. The prevalence of HSP70-1 promoter allele "B" was significantly (p < 0.0004, pc < 0.0012; RR = 5.1) higher in RA patients (22.2%) compared to normal controls (5.3%). It is likely therefore that HSP70-1 promoter allele B is associated with susceptibility to RA.