Related Experiment Videos
Chronic recurrent multifocal osteomyelitis: an evolving clinical and radiological spectrum
M Sundaram1, D McDonald, E Engel
1Department of Radiology, St. Louis University Medical Center, MO 63110-0250, USA.
Skeletal Radiology
|May 1, 1996
Summary
Chronic recurrent multifocal osteomyelitis (CRMO) can present with unusual clinical and radiological features, including associated diseases and atypical patient ages. This highlights the evolving spectrum of CRMO beyond typical pediatric presentations.
Area of Science:
- Medical imaging
- Skeletal pathology
- Immunology
Background:
- Chronic recurrent multifocal osteomyelitis (CRMO) is a rare, non-bacterial osteomyelitis typically affecting children.
- Established diagnostic criteria and typical presentations are well-defined for pediatric CRMO.
Observation:
- This case series describes three patients with CRMO exhibiting atypical clinical and radiological manifestations.
- One patient presented with pyoderma gangrenosum and ulcerative proctitis, while another had a soft tissue mass mimicking sarcoma on MRI.
- The third patient, unusually, presented at age 38 with CRMO lesions in the wrist and phalanges.
Findings:
- The study identified unique associations between CRMO and other conditions, such as inflammatory bowel disease.
- Unusual imaging findings, including soft tissue masses, were observed.
- Late-onset CRMO and unusual lesion locations (hands and feet) were documented.
Implications:
- These findings suggest that the clinical and radiological spectrum of CRMO is broader than previously recognized.
- Clinicians should consider CRMO in adult patients with unexplained bone lesions and unusual comorbidities.
- Further research is needed to understand the evolving nature and full spectrum of CRMO.