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Related Experiment Videos

Compressive myelopathy in fluorosis: MRI

R K Gupta1, P Agarwal, S Kumar

  • 1Department of Radiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Neuroradiology
|May 1, 1996
PubMed
Summary

Fluorosis can cause spinal cord compression due to ossification of spinal ligaments. MRI revealed ligament ossification in four patients with compressive myelopathy, suggesting fluorosis as a potential cause in endemic areas.

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Area of Science:

  • Neurology
  • Radiology
  • Orthopedics

Background:

  • Fluorosis is a public health concern, particularly in endemic regions.
  • Compressive myelopathy can result from various spinal pathologies.
  • Ossification of spinal ligaments, including the posterior longitudinal ligament (PLL) and ligamentum flavum (LF), can lead to cord compression.

Purpose of the Study:

  • To investigate the role of fluorosis in compressive myelopathy.
  • To evaluate MRI findings in patients with fluorosis-associated myelopathy.
  • To highlight fluorosis as a potential cause of spinal ligament ossification and cord compression.

Main Methods:

  • Retrospective analysis of four patients with fluorosis and compressive myelopathy.
  • Magnetic Resonance Imaging (MRI) using spin-echo and fast low-angle shot sequences.

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  • Assessment of spinal cord and ligamentous structures for ossification and signal changes.

    • Main Results:

    • MRI demonstrated cord compression secondary to ossification of the PLL and LF in one patient.
    • Ossification of the LF alone was observed in another patient.
    • Abnormal marrow signal within the PLL and LF was present in all four patients across all MRI sequences.

    Conclusions:

    • Fluorosis should be considered in the differential diagnosis of compressive myelopathy, especially in endemic areas.
    • MRI findings of PLL and/or LF ossification in the context of myelopathy warrant consideration of fluorosis.
    • Early recognition of fluorosis-related spinal changes is crucial for appropriate management.