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Thymulin reduces hyperalgesia induced by peripheral endotoxin injection in rats and mice
B Safieh-Garabedian1, R H Jalakhian, N E Saadé
1Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Lebanon. bared@layla.aub.ac.lb
Brain Research
|April 22, 1996
Abstract:
In a new model of peripheral localized inflammation, induced by intraplantar endotoxin (1.25 micrograms) injection in the hind paw of rats and mice, thymulin, a hormone of the thymus gland involved in immunomodulation, reduced inflammatory pain. High doses of thymulin reduced significantly, and in a dose-dependent manner, mechanical hyperalgesia as assessed by the paw pressure test and thermal hyperalgesia as assessed by the hot plate test and tail immersion test.