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PET-study of intracranial meningiomas: correlation with histopathology, cellularity and proliferation rate
B Lippitz1, U Cremerius, L Mayfrank
1Department of Neurosurgery, Medical Faculty of Technical University Aachen, Federal Republic of Germany.
Abstract:
The glucose metabolism of 62 meningiomas was measured by fluorine -18-2-fluorodeoxyglucose (FDG) PET and correlated with proliferation rate (Ki-67 index) and tumor cellularity. The mean metabolic rate (MRGlu) for meningiomas was 0.26 +/- 0.13 mikromol/g/min (range 0.08-0.62 mikromol/g/min). The relative tumor FDG-uptake (Q-MRGlu) (tumor/contralateral cortex) of all meningiomas was calculated with 0.73 +/- 0.37 (0.24-1.79). Differences of Q-MRGlu were significant between the groups with high vs. low cellularity (p < 0.01), increased vs. normal proliferation rate (p < 0.025) and low (WHO grade I) vs. higher (WHO grades II, III) graded tumors. In recurrent meningiomas (14 tumors) the glucose metabolism was not increased. The data show that 18 FDG-PET is suitable to serve as non-invasive predictor of tumor growth characteristics in meningiomas.
Insights
Fluorine-18-2-fluorodeoxyglucose (FDG) PET scans can predict meningioma growth. This non-invasive imaging method correlates glucose metabolism with tumor characteristics, aiding in diagnosis and prognosis.
Area of Science:
- Neuro-oncology
- Nuclear Medicine
- Oncology
Background:
- Meningiomas are the most common primary brain tumors.
- Accurate assessment of meningioma proliferation and cellularity is crucial for treatment planning.
- Non-invasive methods to predict tumor behavior are highly desirable.
Purpose of the Study:
- To evaluate the utility of fluorine-18-2-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) in assessing glucose metabolism in meningiomas.
- To correlate FDG uptake with tumor proliferation (Ki-67 index) and cellularity.
- To determine if FDG PET can serve as a non-invasive predictor of meningioma growth characteristics.
Main Methods:
- Sixty-two patients with meningiomas underwent FDG PET imaging.
- Tumor glucose metabolism was quantified using metabolic rate (MRGlu) and relative tumor uptake (Q-MRGlu).
- FDG uptake was correlated with Ki-67 proliferation index, tumor cellularity, and WHO tumor grade.
Main Results:
- Significant differences in Q-MRGlu were observed between groups with high vs. low cellularity (p < 0.01).
- FDG uptake varied significantly with proliferation rate (p < 0.025) and WHO tumor grade (I vs. II/III).
- Recurrent meningiomas did not show increased glucose metabolism compared to primary tumors.
Conclusions:
- FDG PET is a valuable non-invasive tool for predicting meningioma growth characteristics.
- FDG uptake correlates with key histopathological features like cellularity and proliferation.
- This imaging modality can aid in the non-invasive stratification of meningioma aggressiveness.