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Histaminergic drugs as modulators of CNS function
1Department of Life Sciences, University of East London, UK.
Pflugers Archiv : European Journal of Physiology
|January 1, 1996
Summary
Histamine plays a key role in brain function, influencing wakefulness, seizures, and more. Understanding histamine receptors (H1, H2, H3) reveals its complex neurotransmitter functions in the central nervous system (CNS).
Area of Science:
- Neuroscience
- Pharmacology
- Biochemistry
Background:
- Initial evidence for histamine's central nervous system (CNS) role emerged from the sedative effects of histamine H1 antagonists.
- Advancements in specific receptor antagonists (H1, H2, H3) have deepened the understanding of histamine's function as a neurotransmitter/modulator.
Purpose of the Study:
- To explore the multifaceted roles of histamine in the CNS.
- To highlight the significance of histamine receptors in various neurological and physiological processes.
Main Methods:
- Review of pharmacological studies involving histamine receptor antagonists.
- Analysis of research linking histaminergic activity to CNS functions and clinical conditions.
Main Results:
- Histamine is implicated in regulating wakefulness, seizure suppression, body temperature, and emesis.
- Histamine H1 antagonists modulate opioid analgesia, feeding behaviors, and pituitary hormone release.
- Antidepressants inhibit histamine-sensitive adenylate cyclase, and H1/H2 receptors may play a role in schizophrenia.
Conclusions:
- Histamine acts as a crucial neurotransmitter/modulator in the brain with diverse functions.
- Further development of specific histaminergic compounds will enhance understanding of its central nervous system roles.