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Hypersensitivity pneumonitis induced by spores of Pholiota nameko
M Inage1, H Takahashi, H Nakamura
1First Department of Internal Medicine, Yamagata University School of Medicine.
Internal Medicine (Tokyo, Japan)
|April 1, 1996
Abstract:
A 42-year-old man experienced recurrent episodes of nonproductive cough, fever, and dyspnea on exertion. He had worked as a mushroom farmer for 10 years. The diagnosis of hypersensitivity pneumonitis was confirmed immunologically by detecting a precipitin to spores of Pholiota nameko but not to other antigens. After separation from the antigen along with an addition of corticosteroid therapy, the symptoms, inflammatory findings and a reduced level of PaO2 quickly subsided.
Insights
Mushroom farmer
Area of Science:
- Pulmonary Medicine
- Immunology
Background:
- Hypersensitivity pneumonitis (HP) is an immune-mediated lung disease.
- Occupational exposures are a common cause of HP.
Observation:
- A 42-year-old mushroom farmer presented with cough, fever, and dyspnea.
- Symptoms were linked to exposure to Pholiota nameko spores.
Findings:
- Immunological confirmation of HP by detecting precipitins to Pholiota nameko spores.
- Successful treatment with antigen avoidance and corticosteroid therapy.
Implications:
- Highlights Pholiota nameko as a specific antigen causing HP.
- Demonstrates effective management strategies for occupational HP.