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Lack of a kinetic interaction between fluconazole and mexiletine
K Ueno1, R Yamaguchi, K Tanaka
1Department of Pharmacy, National Sengokuso Hospital, Osaka, Japan.
Objective:
To investigate the effect of fluconazole on the kinetics of mexiletine.
Methods:
Six healthy male volunteers participated in a crossover study. On the 1st day, the subjects received 200 mg mexiletine alone. On days 2-7 they received 200 mg fluconazole orally, and on day 8 they received 200 mg mexiletine and 200 mg fluconazole concomitantly. In a third phase two subjects received 400 mg fluconazole daily.
Results:
No differences in concentrations were observed between the three phases. The area under the concentration curves (AUC) after administration of mexiletine alone and in combination with fluconazole 200 mg/day were 6.63 and 7.31 micrograms.h.ml-1, respectively.
Conclusion:
These findings suggest that fluconazole does not inhibit mexiletine metabolism.