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Neural involvement in post-traumatic osteopenia: an experimental study in the rat
J E Madsen1, A K Aune, J A Falch
1Institute for Surgical Research, Rikshospitalet, University of Oslo, Sandvike, Norway.
Bone
|May 1, 1996
Summary
Sciatic nerve resection protected against post-traumatic bone loss in rat femora after tibial fracture. This nerve intervention improved bone mineral content and mechanical strength, suggesting systemic effects.
Area of Science:
- Orthopedics
- Neuroscience
- Bone Physiology
Background:
- Post-traumatic bone loss is a significant complication following fractures.
- The role of peripheral nerves in regulating bone metabolism after injury is not fully understood.
Purpose of the Study:
- To investigate the effect of sciatic nerve resection on bone loss and mechanical properties of the femur after tibial fracture.
- To determine if sciatic nerve resection influences ipsilateral and contralateral bone health.
Main Methods:
- 45 male rats underwent tibial fracture and intramedullary nailing.
- Animals were randomized to sciatic nerve resection or sham operation.
- Hindlimbs were immobilized; bone analysis was performed after 25 days.
Main Results:
- Sciatic nerve resection reduced bone mineralization but increased bone mineral content in the ipsilateral femur.
- Femoral shaft mechanical strength (bending moment, energy absorption) was higher in the nerve resection group.
- A protective effect on bone was observed in the contralateral femur, indicating systemic influence.
Conclusions:
- Sciatic nerve resection mitigates post-traumatic bone loss and preserves mechanical strength in the ipsilateral femur.
- Neurectomy demonstrates a protective effect on femoral bone, suggesting a role for the sciatic nerve in post-fracture bone remodeling.
- Systemic effects of sciatic nerve resection on bone metabolism warrant further investigation.