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Related Experiment Videos

A new look at nevus-associated melanomas

S Harley1, N Walsh

  • 1Department of Pathology, Victoria General Hospital, Halifax, Nova Scotia, Canada.

The American Journal of Dermatopathology
|April 1, 1996
PubMed
Summary

Malignant melanomas rarely arise from moles. This study found 23% originated from moles, with acquired moles (Clark

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Radiography (London, England : 1995)·2020

Area of Science:

  • Dermatology and Oncology
  • Pathology of Melanocytic Lesions

Background:

  • Malignant melanoma can arise from pre-existing melanocytic nevi.
  • Understanding the types of nevi associated with melanoma is crucial for early detection.

Purpose of the Study:

  • To investigate the proportion of melanomas arising from acquired versus congenital nevi.
  • To categorize the morphological types of acquired nevi associated with melanoma.

Main Methods:

  • Retrospective analysis of 124 malignant melanoma cases.
  • Classification of associated pre-existing nevi into acquired and congenital types.
  • Morphological subtyping of acquired nevi.

Main Results:

  • Approximately 23% of melanomas were associated with pre-existing nevi.
  • Of these, 55% arose from acquired nevi and 28% from small congenital nevi.
  • The majority of acquired nevi were of Clark's type.

Conclusions:

  • A small fraction of melanomas develop from pre-existing nevi, necessitating balanced early detection strategies.
  • Clark's nevi are known contributors, but the role of small congenital nevi in melanoma development is underrecognized.

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