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Interstitial cystitis: involvement of the intestine
1Department of Urology, Lodge Moor Hospital, Sheffield, UK.
European Urology
|January 1, 1996
Summary
Interstitial cystitis (IC) can affect the intestine, even after bladder reconstruction. This study shows IC symptoms and characteristic histological changes in the intestine of patients who underwent bladder augmentation and diversion.
Area of Science:
- Urology
- Gastroenterology
- Pathology
Background:
- Interstitial cystitis (IC) is a chronic bladder condition.
- Substitution enterocystoplasty involves using intestinal segments to augment the bladder.
- Ileal loop diversion is a surgical procedure for urinary diversion.
Observation:
- Two patients with intractable IC underwent substitution enterocystoplasty and subsequently ileal loop diversion.
- Excised neobladders from both patients showed extensive IC changes in all layers of the intestinal segments.
- One patient experienced persistent IC-like symptoms, with biopsies of the ileal loop revealing characteristic IC histology.
Findings:
- Interstitial cystitis can manifest histologically and symptomatically within intestinal segments used for bladder augmentation and diversion.
- The pathological changes of IC extend beyond the bladder to involve intestinal tissues.
Implications:
- These findings suggest that intestinal segments are susceptible to the pathological processes of interstitial cystitis.
- This expands the understanding of IC's potential reach beyond the bladder.
- Further research is needed to explore the mechanisms and management of IC in intestinal tissues.