Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stromal nodules in benign prostatic hyperplasia

E Bierhoff1, J Vogel, M Benz

  • 1Department of Pathology, Rheinische Friedrich Wilhelms University, Bonn, Germany.

European Urology
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Report of the German Society for Pathology Dermatopathology Working Group].

Pathologie (Heidelberg, Germany)·2024
Same author

High efficacy of red light photodynamic therapy with 10 % aminolevulinic acid gel irrespective of the extent of keratinocyte atypia in actinic keratosis - exploratory post-hoc analysis of three pivotal phase III trials.

Photodiagnosis and photodynamic therapy·2024
Same author

[The possible benefit of artificial intelligence in an organized population-related screening program : Initial results and perspective].

Radiologie (Heidelberg, Germany)·2024
Same author

[Report of the Dermatopathology Working Group of the German Society for Pathology].

Pathologie (Heidelberg, Germany)·2023
Same author

[Report of the meeting of the dermatopathology working group : On Thursday 9 June 2022, 4:30 p.m. to 6:30 p.m., as part of the annual conference of the DGP, in Munster].

Pathologie (Heidelberg, Germany)·2022
Same author

[Rare tumor of the limbus: solitary benign fibrous histiocytoma].

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·2022

Stromal nodules in benign prostatic hyperplasia (BPH) can be classified into four types based on their cellular composition and location. These nodules, which are not found in normal prostates, may develop through a maturational sequence involving immune cells.

Area of Science:

  • Urology
  • Pathology
  • Immunology

Background:

  • Benign prostatic hyperplasia (BPH) is a common condition in aging men.
  • Stromal nodules are a component of BPH, but their nature and development are not fully understood.

Purpose of the Study:

  • To classify stromal nodules in BPH based on their characteristics.
  • To investigate the topography, vascularization, immune cell infiltration, and proliferative activity of stromal nodules.

Main Methods:

  • Histopathology and immunohistochemistry were used to analyze stromal nodules from autopsy and biopsy specimens.
  • Antibodies were employed to identify cytoskeletal components, vascular markers, and immune cells (e.g., T lymphocytes, B lymphocytes).
  • Proliferative activity was assessed using markers like PCNA and MiB1.

Related Experiment Videos

Main Results:

  • Stromal nodules were classified into four types: immature mesenchymal (IM), fibroblastic (FB), fibromuscular (FM), and smooth muscular (SM).
  • Fibroblastic nodules were the most common type (65.2%).
  • Nodules were predominantly found in the transitional and periurethral zones and showed increased infiltration of T and B lymphocytes, with no observed proliferative activity.

Conclusions:

  • Stromal nodules in BPH appear to follow a maturational sequence.
  • Immunocompetent cells may play a role in the development of stromal nodules.
  • Both prostate stroma and epithelium respond to the stimulus causing BPH with nodular hyperplasia.