Related Experiment Videos
Structure-activity relationship studies of xanthone and fluorenone-1,4-dihydropyridine-5-phosphonates
1Department of Pharmaceutical Sciences, University of Bologna, Italy.
Arzneimittel-Forschung
|April 1, 1996
Abstract:
A series of xanthone and fluorenone-1,4-dihydropyridine derivatives bearing a 5-phosphonate group were prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonistic properties. The insertion of a phosphonate group is detrimental for inotropic and calcium antagonistic activity but improves the potency and selectivity for chronotropism.