Related Experiment Videos
Therapy of Lyme borreliosis in children
1J. G. Mendel Children's Hospital, Dept. of Infectious Diseases, Brno, Czech Republic.
Insights
Penicillin and ceftriaxone effectively treated pediatric Lyme borreliosis, including skin manifestations like erythema migrans and neuroborreliosis. Follow-up confirmed no residual illness or lab abnormalities in treated children.
Area of Science:
- Pediatric Infectious Diseases
- Bacteriology
- Immunology
Background:
- Lyme borreliosis, a tick-borne illness, presents with diverse manifestations in children.
- Skin manifestations (erythema migrans, borrelial lymphocytoma) and neuroborreliosis are common pediatric presentations.
- Antibiotic therapy is the cornerstone of Lyme borreliosis treatment.
Purpose of the Study:
- To evaluate the efficacy of penicillin and ceftriaxone in treating pediatric Lyme borreliosis.
- To assess treatment outcomes for skin manifestations and neuroborreliosis.
- To monitor serological responses to antibiotic therapy.
Main Methods:
- Retrospective open study design.
- Inclusion of 160 children treated with penicillin and 41 with ceftriaxone.
- Serological testing for Borrelia antibodies (IgM/IgG) pre-treatment and post-treatment (2-3 and 4-6 weeks).
- Clinical and laboratory follow-up at 3 months.
Main Results:
- Both penicillin and ceftriaxone demonstrated efficacy in treating pediatric Lyme borreliosis.
- Significant reduction in seropositivity observed post-treatment for erythema migrans and neuroborreliosis.
- Borrelial lymphocytoma patients showed a notable increase in IgG seropositivity post-treatment.
- No clinical relapses or laboratory abnormalities were reported at 3-month follow-up.
Conclusions:
- Penicillin and ceftriaxone are effective treatment options for pediatric Lyme borreliosis.
- Antibiotic therapy leads to clinical resolution and serological changes.
- Long-term follow-up confirms sustained efficacy and safety of these antibiotics.
Abstract:
A retrospective open study was conducted to determine the efficacy of penicillin and ceftriaxone in children with skin manifestations of Lyme borreliosis (solitary erythema migrans, multiple erythemata, borrelial lymphocytoma) and neuroborreliosis, respectively. One hundred sixty children were treated with penicillin and 41 with ceftriaxone for an average of 12 days. Serum antibodies to borreliae were determined before therapy and 2-3 and 4-6 weeks thereafter. At admission 44%/26%,8%/42%, and 40%/35% of erythema migrans, borrelial lymphocytoma and neuroborreliosis patients, respectively, were IgM/IgG positive. Four to 6 weeks after treatment the percentage of seropositives was 20%/15%,8%/61%, and 21%/44%, respectively. A 3 months follow-up was completed with 151 children. No child showed clinical evidence of illness, nor were there abnormalities in laboratory parameters.