Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lyme disease vaccine

G P Wormser1

  • 1Division of Infectious Diseases, Westchester County Medical Center, Valhalla, New York 10505, USA.

Infection
|March 1, 1996
PubMed
Summary
This summary is machine-generated.

Single outer surface protein A (OspA) subunit vaccines show promise for Lyme disease prevention in mice. Human trials are ongoing, with local discomfort being the main side effect observed so far.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction for Zhi et al., "Cloning and Expression of the 44-Kilodalton Major Outer Membrane Protein Gene of the Human Granulocytic Ehrlichiosis Agent and Application of the Recombinant Protein to Serodiagnosis".

Journal of clinical microbiology·2023
Same author

Co-infection with HIV-I and HTLV-I/II In Intravenous Drug Users in Suburban New York City, With Comparison to Other Geographic Areas.

Leukemia & lymphoma·2016
Same author

High frequency of false positive IgM immunoblots for Borrelia burgdorferi in clinical practice.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2012
Same author

Lyme borreliosis: the challenge of accuracy.

The Netherlands journal of medicine·2012
Same author

Quantitation of cell-associated borrelial DNA in the blood of Lyme disease patients with erythema migrans.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2011
Same author

Preliminary serologic investigation of 'Rickettsia amblyommii' in the aetiology of Southern tick associated rash illness (STARI).

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2009
Same journal

Changing patterns in the medical care of refugees with HIV from Ukraine.

Infection·2026
Same journal

Trends in meglumine antimoniate prescriptions in Spain (2016-2024): a proxy for cutaneous leishmaniasis burden.

Infection·2026
Same journal

Double agent: how Escherichia coli switches from commensal to pathogen in the urinary tract infection.

Infection·2026
Same journal

Metagenomic next-generation sequencing assists in identifying neurosyphilis: a case series.

Infection·2026
Same journal

Chlamydia trachomatis infection among women with spontaneous abortion in Uganda: burden, clinical presentation, and associated factors in a hospital-based cross-sectional study.

Infection·2026
Same journal

Performance of ultra-sensitive electrochemiluminescence LAM assay for diagnosing tuberculosis in HIV-negative individuals: a multicentre, prospective diagnostic study.

Infection·2026
See all related articles

Area of Science:

  • Immunology
  • Vaccinology
  • Microbiology

Background:

  • Recombinant outer surface proteins (Osp) of Borrelia burgdorferi are effective subunit vaccines in mice.
  • Humoral immunity plays a key role in protection against Lyme disease.
  • A dual vaccine action is proposed, involving host immunity and tick-mediated reduction of spirochetes.

Purpose of the Study:

  • To evaluate the efficacy and safety of monovalent OspA subunit vaccines in human trials.
  • To assess the potential need for multivalent vaccines due to antigen heterogeneity.

Main Methods:

  • Phase III efficacy trials of two different recombinant OspA vaccine preparations in the United States.
  • Monitoring of adverse effects, particularly local discomfort at the injection site.

Related Experiment Videos

Main Results:

  • Monovalent OspA vaccines have demonstrated high efficacy in protecting mice against homologous strains.
  • Local discomfort at the intramuscular injection site is the primary adverse effect reported in human trials.
  • Ongoing data collection for comprehensive safety assessment.

Conclusions:

  • Recombinant OspA vaccines are a promising strategy for Lyme disease prevention.
  • Further safety data are being collected for human vaccines.
  • Multivalent vaccines may be required for broader protection, especially in regions with diverse Borrelia strains like Europe and potentially the US.