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Clinical and histopathological analysis of proliferative potentials of recurrent and non-recurrent meningiomas
A Matsuno1, T Fujimaki, T Sasaki
1Department of Neurosurgery, Teikyo University Ichihara Hospital, Chiba, Japan.
Abstract:
Proliferative potentials of meningiomas from 127 patients were examined immunohistochemically using the anti-Ki-67 monoclonal antibody, MIB-1, on paraffin sections, and the correlation among MIB-1 staining index (SI), histopathological finding, and clinical course of the disease was analyzed retrospectively. The mean MIB-1 SI of 50 male patients with meningioma was 5.5%, whereas that of 77 female patients was 2.7%. Higher MIB-1 SI were observed for younger patients. These age- and sex-related differences in MIB-1 SI were statistically significant. The patients were assigned to one of three groups: those with non-recurrent meningioma (n = 73); those with recurrent meningioma in whom the specimens obtained during the initial surgery were used to calculate the MIB-1 SI (n = 21); and those with recurrent meningioma for whom the specimens obtained during the surgery for recurrent tumors were used to calculate the MIB-1 SI (n = 33). The mean MIB-1 SI in these patients were 1.6%, 3.6%, and 8.8%, respectively, and there were statistically significant differences among these three groups. Statistical analyses reveal that meningiomas with a MIB-1 SI of 3% or more have a significantly high tendency for recurrence during the clinical courses, especially within the first 10-year follow-up periods. Moreover, there is statistically significant correlation between MIB-1 SI and recurrence in each Simpson's grade. The time interval to the next recurrence for recurrent meningiomas is associated with the proliferative potential represented by the MIB-1 SI, and a correlation equation has been proposed to predict the date of the next recurrence. Analyses on cellularity of meningiomas revealed no statistically significant difference in cellularity between non-recurrent and recurrent meningiomas. There was no statistically significant relationship between cellularity and MIB-1 SI of meningiomas. In conclusion, examination on proliferative potentials of meningiomas using MIB-1 SI is very important for biological and histopathological analyses and the prediction of future recurrence.
Insights
Proliferative potential, measured by MIB-1 staining index, predicts meningioma recurrence. Higher MIB-1 SI indicates a greater risk of tumor regrowth, especially within 10 years post-surgery.
Area of Science:
- Neuro-oncology
- Pathology
- Immunohistochemistry
Background:
- Meningiomas are primary tumors of the central nervous system.
- Assessing tumor proliferative potential is crucial for predicting clinical outcomes.
- The Ki-67 antibody (MIB-1) is a widely used marker for cell proliferation.
Purpose of the Study:
- To investigate the correlation between MIB-1 staining index (SI) and meningioma recurrence.
- To analyze the relationship between MIB-1 SI, histopathological findings, and clinical course.
- To explore potential predictors for meningioma recurrence.
Main Methods:
- Immunohistochemical analysis of 127 meningioma patient samples using the MIB-1 antibody.
- Retrospective analysis of MIB-1 SI, histopathological data, and clinical follow-up.
- Statistical correlation analysis between MIB-1 SI, patient demographics, tumor recurrence, and Simpson's grade.
Main Results:
- Statistically significant differences in MIB-1 SI were observed based on patient age and sex.
- Meningiomas with a MIB-1 SI of 3% or higher showed a significantly higher tendency for recurrence.
- A correlation equation was proposed to predict the time interval to the next recurrence based on MIB-1 SI.
Conclusions:
- MIB-1 SI is a valuable tool for assessing meningioma proliferative potential.
- MIB-1 SI is a significant predictor of meningioma recurrence, particularly within the first decade.
- Cellularity did not show a significant correlation with recurrence or MIB-1 SI.