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Related Experiment Videos

Oxidatively modified LDL and atherosclerosis: an evolving plausible scenario

I Jialal1, C J Fuller

  • 1Center for Human Nutrition, University of Texas--Southwestern Medical Center, Dallas 75235-9052, USA.

Critical Reviews in Food Science and Nutrition
|April 1, 1996
PubMed
Summary

Antioxidant nutrients like alpha-tocopherol, ascorbic acid, and betacarotene can inhibit low-density lipoprotein (LDL) oxidation. Supplementation may offer a promising strategy for preventing coronary artery disease.

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Area of Science:

  • Cardiovascular science
  • Nutritional science
  • Oxidative stress research

Background:

  • Oxidative modification of low-density lipoprotein (LDL) is implicated in early atherogenesis.
  • Antioxidant nutrients play a role in mitigating oxidative damage.

Purpose of the Study:

  • To evaluate the potential of antioxidant nutrients in preventing LDL oxidation.
  • To assess the efficacy of alpha-tocopherol, ascorbic acid, and betacarotene supplementation.

Main Methods:

  • In vitro studies assessing LDL oxidation inhibition.
  • In vivo studies in animals and humans measuring LDL oxidation resistance after nutrient administration.

Main Results:

  • Alpha-tocopherol, ascorbic acid, and betacarotene demonstrated inhibition of LDL oxidation in vitro.

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  • Supplementation increased LDL resistance to oxidation in both animal and human subjects.
  • Dietary supplementation with these nutrients can be achieved with minimal side effects.

    • Conclusions:

    • Antioxidant nutrients show promise in preventing LDL oxidation.
    • Increased plasma levels of these nutrients via supplementation may be beneficial for coronary artery disease prevention.