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Synthesis, structure and stability of novel dimeric peptide-disulfides
J J Leban1, A Spaltenstein, A Landavazo
1Wellcome Research Laboratories, Research Triangle Park, North Carolina, USA.
International Journal of Peptide and Protein Research
|March 1, 1996
Abstract:
Oxidation of nonapeptide dithiol (2) with K3Fe(CN)6 leads to either monomeric disulfide (4) or antiparallel and parallel dimeric disulfides (3a and 3b) depending upon reaction conditions. When exposed to small amounts of thiols or cyanide in aqueous solution, these three species interconvert to an equilibrium mixture of 2:1:8 (3a:3b:4).