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Cranio-orbital teratoma
J U Prause1, S E Børgesen, H Carstensen
1Eye Pathology Institute, University of Copenhagen, Denmark.
Insights
A rapidly growing tumor in a newborn, involving the orbit and brain, was identified as a secondary orbital teratoma. Surgical removal was performed, with recurrence noted later.
Area of Science:
- Pediatric Oncology
- Neurosurgery
- Ophthalmology
Background:
- Orbital and intracranial tumors are rare in newborns.
- Rapidly growing masses pose significant diagnostic and therapeutic challenges.
Observation:
- A neonate presented with a large, rapidly enlarging tumor affecting the right orbit and anterior intracranial space.
- The tumor extended through the temporal bone, causing proptosis and eye rupture.
- Surgical extirpation was performed at 12 days old, followed by a second surgery for recurrence two months later.
Findings:
- The tumor was classified as a secondary orbital teratoma based on its extensive orbital and intracranial involvement.
- Histopathological examination revealed a benign teratoma containing elements from all three germinal layers.
- The tumor's origin was likely the superior orbital fissure.
Implications:
- This case highlights the aggressive nature and potential for recurrence of secondary orbital teratomas in neonates.
- Early diagnosis and aggressive surgical management are crucial for managing these rare congenital tumors.
- Further research into the embryogenesis and optimal treatment strategies for orbital teratomas is warranted.
Abstract:
A new-born baby presented with a large, rapidly growing tumour. The tumour involved the right orbit, the anterior half of the right intracranial space and extended through the skull of the temporal region. The proptotic eye ruptured due to exposure. The tumour was extirpated when the patient was 12 days old. A large recurrence was extirpated two months later. The tumour was firmly bound to the medial aspect of the superior orbital fissure which probably was the location of origin of the tumour. Based on the size of the intracranial-and the orbital part of the tumour, it was classified as a secondary orbital teratoma. The tumour was macroscopically composed of cystic and solid areas. Microscopically it was seen to be a benign teratoma with tissue from all three germinal layers.