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Therapy of Behçet's disease
1Medizinische Universitätsklinik, Abteilung II-Rheumatologie/ Klinische Immunologie, Universität Tübingen, Germany.
German Journal of Ophthalmology
|March 1, 1996
Summary
For Behçet
Area of Science:
- Rheumatology
- Ophthalmology
- Dermatology
Background:
- Behçet's disease (BD) is a multisystem vasculitis with unknown etiology.
- This study retrospectively analyzed 32 BD patients treated between 1978-1993.
Purpose of the Study:
- To evaluate the efficacy of various therapeutic strategies for different organ manifestations of Behçet's disease.
- Specifically focusing on the effectiveness of treatments for ocular involvement.
Main Methods:
- Retrospective analysis of patient data from Tübingen University Clinic.
- Evaluation of treatments including colchicine, azathioprine, cyclosporine, steroids, and interferons.
Main Results:
- Combination therapy (cyclosporine, azathioprine, steroids) achieved complete remission in Behçet's disease patients.
- Interferon-gamma showed limited efficacy, while interferon-alpha induced remission in one patient.
- Azathioprine and steroid combination was effective for uveitis, with a triple combination yielding higher remission rates.
Conclusions:
- For mucocutaneous disease and arthritis in Behçet's disease, interferons may be beneficial.
- For severe manifestations like uveitis, cyclosporine or azathioprine with steroids are recommended.
- A combination of azathioprine, cyclosporine, and steroids represents a highly effective treatment option for refractory cases.