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[Multiple cerebral infarction after treatment with cisplatin]
S Komatsumoto1, T Ushioda, M Nara
1Department of Internal Medicine, Ashikaga Red Cross Hospital, Japan.
Rinsho Shinkeigaku = Clinical Neurology
|March 1, 1996
Summary
Cisplatin chemotherapy, used for cervical cancer, can cause cerebrovascular accidents (stroke) due to blood clot formation. This rare complication may result from damage to blood vessel linings, leading to stroke.
Area of Science:
- Oncology
- Neurology
- Vascular Medicine
Background:
- Cisplatin is a widely used chemotherapy agent for various cancers, including cervical cancer.
- Cerebrovascular accidents (stroke) are a known but rare complication associated with chemotherapy.
- Understanding the mechanisms of chemotherapy-induced neurotoxicity is crucial for patient safety.
Observation:
- A 46-year-old woman developed acute memory disturbance and right-sided weakness five days after her eleventh cycle of cisplatin chemotherapy for cervical cancer.
- Neurological examination revealed a right-sided pyramidal sign.
- Brain MRI demonstrated multiple infarctions in the left basal ganglia.
Findings:
- The patient had no identifiable coagulopathy, vascular, or endocardial disease predisposing to stroke.
- The clinical presentation and imaging findings suggest a thrombotic event.
- The temporal association with cisplatin therapy points to a potential drug-induced mechanism.
Implications:
- Cisplatin-induced vascular endothelial injury may lead to thrombosis and cerebrovascular complications.
- This case highlights the importance of monitoring for neurological adverse events during cisplatin therapy.
- Further research is warranted to elucidate the precise mechanisms and identify at-risk patients.