Related Experiment Videos
[Clinical problems in surgical treatment for active infective endocarditis]
1Second Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Kyobu Geka. the Japanese Journal of Thoracic Surgery
|July 1, 1996
Summary
Early surgery for infective endocarditis is crucial. Patients with uncontrolled infections, indicated by positive cultures or sepsis markers, benefit from prompt operative intervention to reduce mortality.
Area of Science:
- Cardiovascular Surgery
- Infectious Diseases
- Medical Microbiology
Context:
- Active infective endocarditis poses significant surgical challenges.
- Surgical treatment outcomes vary based on preoperative infection control.
Purpose:
- To evaluate the impact of preoperative uncontrolled infection on operative mortality in patients with active infective endocarditis undergoing surgery.
- To identify indicators of uncontrolled infection that predict surgical outcomes.
Summary:
- A study of 22 patients with active infective endocarditis found that those with microorganisms detected preoperatively (group P) had a significantly higher operative mortality (50%) compared to those without (group N, 0%).
- Prolonged preoperative uncontrolled infection (over 8 days) in group P led to an 83% 30-day mortality.
- Early surgical intervention within seven days of diagnosis is recommended for patients not responding to antibiotics.
Impact:
- Findings suggest that early surgical intervention for infective endocarditis, particularly in patients with persistent infection, can significantly decrease operative mortality.
- Plasma C-reactive protein (CRP) levels and sepsis definitions may serve as valuable indicators for assessing infection control and guiding surgical timing.