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[Role of apoptosis in renal injury]

H Sugiyama1, N Kashihara, H Makino

  • 1Third Department of Internal Medicine, Okayama University Medical School.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|July 1, 1996
PubMed

Insights

Apoptosis, or programmed cell death, is implicated in kidney diseases. Regulating apoptosis could be key for treating renal disorders like glomerular and tubular diseases.

Area of Science:

  • Nephrology
  • Cell Biology

Context:

  • Apoptosis (programmed cell death) is increasingly recognized in renal pathology.
  • Abnormal apoptosis contributes to glomerular and tubular kidney diseases.

Purpose:

  • To review the role of apoptosis in various renal diseases.
  • To highlight the significance of apoptosis regulation in kidney disease treatment.

Summary:

  • Excess apoptosis can cause glomerular sclerosis, while increased apoptosis resolves mesangial hypercellularity.
  • Apoptosis is linked to tubular atrophy, damage from ischemia-reperfusion or toxins, and polycystic kidney disease.
  • Leukocyte apoptosis occurs during renal inflammation, indicating its broad involvement.

Impact:

  • Understanding apoptosis mechanisms is crucial for developing novel therapeutic strategies for kidney diseases.
  • Targeting apoptosis offers potential for managing conditions like glomerular sclerosis and tubular damage.

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