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[Two cases of Listeria monocytogenes infection in Osaka Municipal Hospital]
N Tamagawa1, T Adachi, Y Tsubakio
1Juso Citizens' Hospital, Osaka, Japan.
Abstract:
We report two cases of sepsis and meningoencephalitis with listeriosis. They died in despite of administering sensitive antibiotics. A 2 day old girl was admitted to our hospital because of fever and cyanosis. Listeria monocytogenes type 4b was cultured from blood, CSF, throat, urine, ear. She was treated with twice exchange transfusion and sensitive antibiotics (ABPC, TOB), but died from DIC. A 48 year old man suddenly experienced an unconscious condition. A CSF culture grew L. monocytogenes type 1/2a. He was treated with sensitive antibiotics (ABPC, CEZ etc), but went bad conditions. Listeria infection of this cases developed as unfortunate infection.
Insights
Two cases of Listeria monocytogenes infection, causing sepsis and meningoencephalitis, were fatal despite antibiotic treatment. This highlights the severe and often deadly nature of listeriosis, even with medical intervention.
Area of Science:
- Infectious Diseases
- Neurology
- Microbiology
Background:
- Listeriosis, caused by Listeria monocytogenes, is a serious infection that can lead to sepsis and meningoencephalitis.
- Early diagnosis and prompt treatment are crucial for managing severe Listeria infections.
Observation:
- A 2-day-old infant presented with fever and cyanosis, diagnosed with Listeria monocytogenes type 4b sepsis and meningoencephalitis.
- A 48-year-old man experienced sudden unconsciousness, with cerebrospinal fluid culture revealing Listeria monocytogenes type 1/2a meningitis.
Findings:
- Both patients received sensitive antibiotics and appropriate medical care, including exchange transfusion for the infant.
- Despite aggressive treatment, both cases resulted in mortality, with the infant succumbing to disseminated intravascular coagulation (DIC).
Implications:
- This report underscores the critical challenge of treating severe Listeria infections, particularly in neonates and immunocompromised individuals.
- Further research into novel therapeutic strategies is warranted to improve outcomes for patients with invasive listeriosis.