Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Engrailed, Wnt and Pax genes regulate midbrain--hindbrain development

A L Joyner1

  • 1Department of Cell Biology, New York University Medical Center, NY 10016-0497, USA. Joyner@mcbi-34.med.nyu.edu

Trends in Genetics : TIG
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Buckling without Bending: A New Paradigm in Morphogenesis.

Physical review. X·2019
Same author

A Study of the Action of a Filtrable Staphylococcal Toxin on the Kidneys of Normal Rabbits.

The American journal of pathology·2009
Same author

ALTERED CUTANEOUS CONDITIONS IN THE SKIN OF TUBERCULOUS GUINEA PIGS AS DEMONSTRATED WITH A VITAL DYE.

The Journal of experimental medicine·2009
Same author

CELLULAR REACTIONS TO POLYSACCHARIDES FROM TUBERCLE BACILLI AND FROM PNEUMOCOCCI.

The Journal of experimental medicine·2009
Same author

TUBERCULAR ALLERGY WITHOUT INFECTION.

The Journal of experimental medicine·2009
Same author

CELLULAR REACTIONS TO DEFATTED TUBERCLE BACILLI AND THEIR PRODUCTS.

The Journal of experimental medicine·2009

Mouse Engrailed, Wnt, and Pax genes are crucial for vertebrate mesencephalon and metencephalon development. These conserved genes, similar to Drosophila segmentation genes, control brain region formation and organization.

Area of Science:

  • Developmental biology
  • Neuroscience
  • Genetics

Background:

  • Vertebrate brain development relies on conserved genetic networks.
  • Drosophila segmentation genes have homologous counterparts in vertebrates.

Purpose of the Study:

  • To investigate the role of mouse Engrailed, Wnt, and Pax genes in mesencephalon and metencephalon development.
  • To understand the genetic control and organizational principles of early brain region formation.

Main Methods:

  • Analysis of mutant phenotypes and gene expression data.
  • Ectopic transplantation studies of the midbrain-hindbrain junction.

Main Results:

  • Six gene family members are essential for the early formation of the mesencephalon and metencephalon.

Related Experiment Videos

  • The midbrain-hindbrain junction acts as an organizer, recruiting host cells.

    • Conclusions:

    • The mesencephalon and metencephalon develop as a single, independent unit.
    • Conserved genes controlling Drosophila segmentation are involved in vertebrate brain development.
    • Brain segmentation may be understood as 'genetic units'.