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Enhanced antitumor activity of an adriamycin + 5-fluorouracil combination when preceded by biochemical modulation
R L Stolfi1, J R Colofiore, L D Nord
1Catholic Medical Center, Woodhaven, NY 11421, USA.
Anti-Cancer Drugs
|January 1, 1996
Abstract:
A three-drug combination, PMA, consisting of (phosphonacetyl)-L-aspartic acid + 6-methylmercaptopurine riboside + 5-aminonicotinamide, preceding either 5-fluorouracil (5-FU) or adriamycin (Adr), produced tumor-regressing activity in a murine advanced breast tumor model not attainable with either 5-FU or Adr as single agents, or with any lesser combination of these drugs administered at maximally tolerated doses. Marked tumor-regressing activity was further increased significantly by using 5-FU and Adr together in conjunction with the modulatory biochemical conditioning (particularly ATP depletion) provided by pretreatment with PMA.