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Abnormalities of leukotaxis in atopic dermatitis
The Journal of Allergy and Clinical Immunology
|August 1, 1977
Summary
Patients with severe atopic dermatitis often exhibit abnormal leukocyte chemotaxis, specifically reduced monocyte chemotactic responsiveness. These immune cell defects may be linked to serum inhibitors, warranting further investigation into their clinical significance.
Area of Science:
- Immunology
- Dermatology
Background:
- Atopic dermatitis is a chronic inflammatory skin condition.
- Leukocyte dysfunction may contribute to the pathogenesis of atopic dermatitis.
Purpose of the Study:
- To investigate leukocyte chemotactic responsiveness in patients with atopic dermatitis.
- To identify potential serum factors affecting immune cell migration.
Main Methods:
- Assessed monocyte chemotactic responsiveness (MCR) and polymorphonuclear leukocyte (PMN) chemotactic responsiveness (PCR) in 14 atopic dermatitis patients.
- Evaluated patient serum for inhibition of normal monocyte chemotaxis.
Main Results:
- Depressed MCR was observed in 8/14 patients, with serum inhibitors present in 5/8.
- Depressed PCR was found in 3/10 patients.
- Ten patients showed impaired chemotaxis of at least one cell type, unrelated to infection, IgE levels, or eczema severity.
Conclusions:
- A high frequency of leukocyte chemotactic abnormalities exists in severe atopic dermatitis.
- The clinical significance and origin (primary vs. secondary) of these immune cell defects require further study.
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