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Updated: Aug 11, 2026

Viability Assays for Cells in Culture
Published on: January 20, 2014
Protection against veratridine toxicity in rat cortical cultures: relationship to sodium channel blockade
Abstract:
Neuroprotection against 100 microM veratridine-induced cell death and inhibition of voltage-dependent sodium currents by phenytoin, carbamazepine, lidocaine and vinpocetine were studied in rat primary cerebrocortical cultures. Neuroprotective efficacies and sodium channel blocking potencies of these drugs failed to show a correlation, suggesting that (i) mechanisms other than sodium channel blockade may be involved in the neuroprotection, and/or (ii) inhibitory efficacy against veratridine- and voltage-activated channels may differ remarkably.
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