Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Olfactory experience modulates Bcl-2 expression in the developing olfactory bulb

J Najbauer1, E Ibrahim, M Leon

  • 1Department of Psychobiology, University of California, Irvine 92717-4550, USA.

Neuroreport
|December 29, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient organ dose assessment during radioactive iodine treatments of benign thyroid diseases.

Radiography (London, England : 1995)·2025
Same author

The role of shared decision-making in enhancing patient experience: Insights from a cohort of curative head and neck cancer patients.

Radiography (London, England : 1995)·2024
Same author

Spatio-Temporal Pattern of Tuberculosis Distribution in Romania and Particulate Matter Pollution Associated With Risk of Infection.

GeoHealth·2024
Same author

Mechanical ventilation in Spain, 1998-2016: Changes in the disconnection of mechanical ventilation.

Medicina intensiva·2022
Same author

Mechanical ventilation in Spain, 1998-2016: changes in the disconnection of mechanical ventilation.

Medicina intensiva·2021
Same author

Mechanical ventilation in Spain, 1998-2016: Epidemiology and outcomes.

Medicina intensiva·2020
Same journal

Electroacupuncture alleviates neuroinflammation and promotes recovery of neurological functions after intracerebral hemorrhage by modulating α7nAChR/JAK2/STAT3 signaling pathway.

Neuroreport·2026
Same journal

Non-cell-autonomous regulation of Bhlhb5 expression in cortical projection neurons by GABAergic interneuron development and position.

Neuroreport·2026
Same journal

C-C motif chemokine ligand 3 mediates inflammatory response via NLRP3 inflammasome and neuron damage after traumatic brain injury.

Neuroreport·2026
Same journal

Methyltransferase-like 14 alleviates neuronal ferroptosis in Alzheimer's disease by regulating the peroxiredoxin 6/apoptosis signal-regulating kinase 1 signaling pathway.

Neuroreport·2026
Same journal

Hand mental rotation reaction time reflects motor imagery strategy and predicts changes in finger dexterity after motor imagery.

Neuroreport·2026
Same journal

Functional exploration of metabotropic glycine receptors in cultured rat hippocampal slices.

Neuroreport·2026
See all related articles

Olfactory deprivation increases Bcl-2 gene expression in rat olfactory bulbs, suggesting a role in neural plasticity and cell survival. This finding highlights how sensory experience influences gene regulation in the brain.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • The olfactory bulb is crucial for processing scent information.
  • Cellular mechanisms underlying neural plasticity in the olfactory system are not fully understood.
  • The Bcl-2 gene plays a key role in regulating cell survival and apoptosis.

Purpose of the Study:

  • To investigate the effect of olfactory deprivation on Bcl-2 gene expression in the olfactory bulb of young rats.
  • To explore the relationship between Bcl-2 expression, apoptosis, and olfactory experience.

Main Methods:

  • Olfactory deprivation was induced in young rats.
  • Bcl-2 messenger RNA (mRNA) expression levels were measured in the olfactory bulb.
  • Cellular layers of the olfactory bulb were analyzed for changes in gene expression.

Related Experiment Videos

  • Apoptosis incidence was assessed in relation to Bcl-2 mRNA levels.

    • Main Results:

    • Olfactory deprivation led to a significant increase in Bcl-2 mRNA expression across various layers of the olfactory bulb.
    • Specific regions, including the glomerular and external plexiform layers, showed notable increases.
    • An inverse correlation was observed between apoptosis and Bcl-2 mRNA expression in the glomerular layer.
    • Control groups without olfactory manipulation showed no significant changes.

    Conclusions:

    • Bcl-2 gene expression is upregulated in response to olfactory deprivation in young rats.
    • Increased Bcl-2 expression may play a protective role against apoptosis induced by sensory loss.
    • These findings suggest that Bcl-2 is involved in olfactory experience-related neural plasticity and cell survival regulation.