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Related Experiment Videos

Diminished thyroxine-binding globulin in pubertal diabetic children

M H Connors1, D B Dunger, H Chapel

  • 1Department of Pediatrics, University of California, Davis, USA. mhconnors@ucdavis.edu

Diabetes Care
|March 1, 1996
PubMed
Summary

Diabetes can lower thyroid hormone (TT4) and thyroxine-binding globulin (TBG) levels in adolescents. Monitoring free thyroid hormone and TSH is crucial for diabetic youth to ensure normal thyroid function.

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Area of Science:

  • Endocrinology
  • Pediatric Endocrinology
  • Metabolic Disorders

Background:

  • Diabetes mellitus can impact various endocrine functions.
  • Thyroid hormone homeostasis is essential during adolescent development.
  • Thyroxine-binding globulin (TBG) influences thyroid hormone availability.

Purpose of the Study:

  • To investigate the effects of diabetes on thyroid hormone (total thyroxine [TT4] and free thyroxine [FT4]) and TBG concentrations in adolescents.
  • To assess puberty-related changes in thyroid parameters in diabetic versus non-diabetic youth.

Main Methods:

  • Cross-sectional study comparing 171 thyroid microsomal antibody-negative adolescents with normal TSH levels.
  • Measurement of TT4, FT4, and TBG in diabetic and control groups.

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  • Analysis of puberty-related changes and correlations with diabetes duration and glycemic control (HbA1c).

    • Main Results:

    • Diabetic adolescents, particularly girls, exhibited lower TT4 levels compared to controls.
    • TT4 levels correlated positively with TBG in both sexes.
    • TBG levels were reduced across pubertal stages in both genders.
    • Higher TT4 and FT4 levels were observed in girls with better glycemic control (lower HbA1c).

    Conclusions:

    • Diabetes is associated with decreased TT4 and TBG levels in adolescents.
    • Low TT4 levels in diabetic youth correlate with reduced TBG.
    • Measuring free thyroid hormone and TSH is recommended for diabetic adolescents to confirm euthyroid status.