Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antihypertensive treatment in the elderly

L H Lindholm1

  • 1Department of Community Health Sciences, Lund University, Helgeandsgatan, Sweden.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|April 1, 1996
PubMed
Summary

Treating hypertension in adults aged 70+ with beta-blockers and diuretics significantly reduces cardiovascular events and mortality. This blood pressure lowering therapy is cost-effective and should be considered for elderly patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lowering Albuminuria-Does It Lower the Cardiovascular Risk?: Reduction in Albuminuria Translates to Reduction in Cardiovascular Events in Hypertensive Patients: Losartan Intervention for Endpoint Reduction in Hypertension Study. Hypertension 45: 198-202, 2005.

Journal of the American Society of Nephrology : JASN·2023
Same author

Reducing Microalbuminuria-Does It Lower Cardiovascular Risk?: Reduction in Albuminuria Translates to Reduction in Cardiovascular Events in Hypertensive Patients: Losartan Intervention for Endpoint Reduction in Hypertension Study. Hypertension 45: 198-202, 2005.

Journal of the American Society of Nephrology : JASN·2023
Same author

In-treatment HDL cholesterol levels and development of new diabetes mellitus in hypertensive patients: the LIFE Study.

Diabetic medicine : a journal of the British Diabetic Association·2013
Same author

International Society of Hypertension Low and Middle Income Countries Committee: Review of the goals of the Committee and of 5 years of ISH activities in low and middle income countries.

Journal of hypertension·2010
Same author

Reduction in albuminuria translates to reduction in cardiovascular events in hypertensive patients with left ventricular hypertrophy and diabetes.

Journal of nephrology·2008
Same author

The effect of losartan compared with atenolol on the incidence of revascularization in patients with hypertension and electrocardiographic left ventricular hypertrophy. The LIFE study.

Journal of human hypertension·2006

Area of Science:

  • Geriatric Medicine
  • Cardiovascular Pharmacology
  • Public Health

Background:

  • Elderly individuals (70 years and above) frequently have hypertension, a significant risk factor for cardiovascular disease.
  • Effective and cost-efficient antihypertensive strategies are crucial for this demographic to reduce morbidity and mortality.

Purpose of the Study:

  • To evaluate the efficacy and cost-effectiveness of beta-blockers and diuretics in reducing cardiovascular events in elderly hypertensive patients.
  • To determine the clinical implications for blood pressure management in individuals aged 70 and older.

Main Methods:

  • Analysis of drug treatment outcomes, specifically focusing on cardiovascular morbidity and mortality in hypertensive men and women aged 70+.
  • Assessment of drug tolerability and cost-effectiveness ratios, including comparisons between genders.
  • Consideration of co-existing conditions and the need for adjusted pharmacological approaches (e.g., calcium antagonists, ACE inhibitors).

Main Results:

  • Beta-blockers and diuretics significantly reduce cardiovascular (especially stroke) morbidity and mortality in hypertensive individuals aged 70 and above.
  • The positive treatment effects are not diminished by the drugs' tolerability profiles.
  • Treatment is cost-effective, with low cost-effectiveness ratios observed for both men and women in the STOP-Hypertension study.

Conclusions:

  • Blood pressure lowering therapy, particularly with beta-blockers and/or diuretics, is clinically indicated and cost-effective for elderly hypertensives up to age 80.
  • Treatment regimens should be individualized, considering comorbidities and potentially incorporating agents like calcium antagonists or ACE inhibitors when necessary.

Related Experiment Videos