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The role of beta 2-glycoprotein I in the antiphospholipid syndrome
S A Krilis1, Y H Sheng, D A Kandiah
1Department of Immunology, Allergy and Infectious Disease, St George Hospital University of NSW, Australia.
Lupus
|April 1, 1996
Abstract:
Antiphospholipid antibodies were originally thought to bind negatively-charged (anionic) phospholipids. Current evidence suggest that the target antigen is considerably more complex and includes beta 2-glycoprotein I, a phospholipid-binding plasma protein. Our understanding of the pathophysiology of the antiphospholipid syndrome has increased exponentially with a number of studies into the interactions of antiphospholipid antibodies and beta 2-glycoprotein I.