Laboratory detection of antiphospholipid antibodies
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Updated: Oct 14, 2026
Antibody Profiling by Luciferase Immunoprecipitation Systems (LIPS)
Published on: October 7, 2009
1Department of Immunology, Allergy and Infectious Disease, University of New South Wales, St George Hospital, Kogarah, Australia.
Abstract:
'Antiphospholipid' (aPL) antibodies are a heterogenous group of autoantibodies that are now considered to be directed mainly to plasma proteins or protein-phospholipid complexes. Standardisation of assays for anticardiolipin (aCL) antibodies and lupus anticoagulants (LA) have been fraught with difficulty despite numerous attempts to perform this by International Standardisation Workshops and Committees.
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