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Platelet density and size in inflammatory bowel disease
1Department of Clinical Chemistry, Orebro Medical Center Hospital, Sweden.
Objective:
The present study investigates platelet density and mean platelet volume (MPV) in active inflammatory bowel disease (IBD).
Experimental Protocol:
27 patients with IBD (18 ulcerative colitis and 9 Crohn's disease) were compared to 12 healthy volunteers. 18 subjects had active disease. Platelet counts and mean platelet volume (MPV) were determined. Thereafter, platelets were separated according to density on a linear preformed Percoll gradient. A computerized device was employed for scanning transmission variations and thus the platelet distribution in the gradient and the platelet peak were identified.
Results And Conclusions:
Subjects with active IBD had greater platelet density (p = 0.02) and lower MPVs (p < 0.001). These findings may indicate augmented platelet granule content. The study also demonstrates that a low MPV is associated with active IBD.