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Platelet density and size in inflammatory bowel disease
1Department of Clinical Chemistry, Orebro Medical Center Hospital, Sweden.
Thrombosis and Haemostasis
|April 1, 1996
Summary
Active inflammatory bowel disease (IBD) is linked to increased platelet density and lower mean platelet volume (MPV). This suggests changes in platelet granule content in patients with active IBD.
Area of Science:
- Gastroenterology
- Hematology
- Immunology
Background:
- Inflammatory bowel disease (IBD) encompasses chronic conditions like ulcerative colitis and Crohn's disease.
- Platelets play a role in inflammation and immune responses.
- Alterations in platelet indices may be associated with inflammatory conditions.
Purpose of the Study:
- To investigate platelet density and mean platelet volume (MPV) in patients with active inflammatory bowel disease (IBD).
Main Methods:
- Compared 27 IBD patients (18 ulcerative colitis, 9 Crohn's disease) with 12 healthy volunteers.
- Determined platelet counts and MPV.
- Separated platelets by density using Percoll gradients and analyzed platelet distribution via a computerized device.
Main Results:
- Subjects with active IBD exhibited significantly greater platelet density (p = 0.02).
- Active IBD patients showed significantly lower MPVs (p < 0.001).
Conclusions:
- Findings suggest augmented platelet granule content in active IBD.
- A low MPV is demonstrably associated with active inflammatory bowel disease.