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Asthma as an inflammatory disease: implications for management

W K Dolen1

  • 1Department of Pediatrics, Medical College of Georgia, Augusta 30912, USA.

The Journal of the American Board of Family Practice
|May 1, 1996
PubMed
Summary

Eosinophilic inflammation is key in asthma, driving airway hyperresponsiveness. New therapies focus on reducing this inflammation, improving asthma management alongside bronchodilators.

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Area of Science:

  • Pulmonary Medicine
  • Immunology
  • Pathophysiology

Background:

  • Eosinophilic inflammation is central to asthma pathogenesis across all disease severities.
  • Airway inflammation correlates with airway hyperresponsiveness, a key asthma abnormality.
  • Inflammation is initiated by immunologic events and driven by immune cell mediators.

Purpose of the Study:

  • To review the role of inflammation in asthma.
  • To highlight the shift towards anti-inflammatory therapies in asthma management.

Main Methods:

  • Literature review of recent articles on asthma and inflammation.
  • Information sourced from journal clubs and the National Library of Medicine.

Main Results:

  • Asthma inflammation involves six steps: triggering, signaling, migration, cell activation, tissue damage, and resolution.
  • Research and therapeutic development now target airway inflammation reduction.
  • Anti-inflammatory therapy effectively reduces bronchial hyperresponsiveness.

Conclusions:

  • Understanding inflammation's role has redirected asthma research and therapy.
  • Anti-inflammatory management is crucial for asthma control.
  • Short-acting beta-2 agonists remain essential for acute symptoms and some patients require regular use.

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