Hepatocyte death following transforming growth factor-beta 1 addition
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Updated: Nov 5, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
F Oberhammer1, G Froschl, R Tiefenbacher
1MRC Toxicology Unit, University of Leicester, United Kingdom.
Abstract:
Apoptosis is a morphological term which describes a sequence of events finally leading to cell death. In epithelial organs, induction of cell death is closely linked to an inhibitor of epithelial growth, transforming growth factor-beta 1 (TGF-beta 1). In this paper, we describe the morphology of TGF-beta 1-induced apoptosis in hepatocytes of the hyperplastic liver and primary cultures. Chromatin condensation, a hallmark of apoptosis, was observed in primary hepatocytes by confocal and vital UV microscopy. In addition, we have applied the morphological detection of DNA strand breaks both by in situ tailing (ISTAIL) and in situ nick translation (ISNT).
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