Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Profound bilateral sensorineural hearing loss during gentamicin therapy

D A Moffat, R T Ramsden

    The Journal of Laryngology and Otology
    |June 1, 1977
    PubMed
    Summary

    Gentamicin therapy can cause profound hearing loss, though some recovery is possible. This case highlights the importance of careful gentamicin use and monitoring for ototoxicity, especially in patients with normal vestibular function.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Surgery of the lateral skull base: a 50-year endeavour.

    Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale·2019
    Same author

    Bilateral vestibular schwannomas in older patients: NF2 or chance?

    Journal of medical genetics·2015
    Same author

    Factors affecting final facial nerve outcome following vestibular schwannoma surgery.

    The Journal of laryngology and otology·2014
    Same author

    The management of cochlear nerve deficiency.

    Cochlear implants international·2014
    Same author

    Outcome of translabyrinthine surgery for vestibular schwannoma in neurofibromatosis type 2.

    British journal of neurosurgery·2013
    Same author

    Cortical activations in sequential bilateral cochlear implant users.

    Cochlear implants international·2011

    Area of Science:

    • Ototoxicology
    • Nephrology
    • Audiology

    Background:

    • Gentamicin is a potent antibiotic used for severe bacterial infections.
    • Ototoxicity, including sensorineural hearing loss, is a known but infrequent side effect of gentamicin.
    • Predisposing factors for gentamicin ototoxicity require careful consideration.

    Observation:

    • A case of profound bilateral sensorineural deafness occurred during gentamicin treatment.
    • Significant hearing recovery was noted in the right ear, but the left ear remained deaf.
    • Electrocochleography confirmed the damage originated from the inner ear's sensory organs.

    Findings:

    • The patient experienced sudden, severe hearing loss without concurrent vestibular dysfunction, an unusual presentation.
    • The incidence of gentamicin-induced ototoxicity is estimated at 2-3%.

    Related Experiment Videos

  • Risk factors and the need for vigilant monitoring of renal function and antibiotic levels are crucial.

    • Implications:

    • Gentamicin should be reserved for life-threatening infections where benefits outweigh risks.
    • Awareness of predisposing factors can help mitigate the risk of ototoxicity.
    • Close monitoring of hearing and kidney function is essential during gentamicin therapy.