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Primary sclerosing cholangitis: an experience from India

R Kochhar1, M K Goenka, K Das

  • 1Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Journal of Gastroenterology and Hepatology
|May 1, 1996
PubMed
Summary

Primary sclerosing cholangitis (PSC) is not rare in India, with a similar clinical profile and outcome to Western countries. This study investigated PSC incidence, presentation, and results in a tertiary care center.

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Area of Science:

  • Gastroenterology
  • Hepatology
  • Cholangiology

Background:

  • Primary sclerosing cholangitis (PSC) is often considered rare in India.
  • Understanding its incidence and characteristics in the Indian population is crucial for diagnosis and management.

Purpose of the Study:

  • To investigate the incidence, clinical profile, and outcomes of PSC in a tertiary care center in India.
  • To compare findings with those reported in Western countries.

Main Methods:

  • Retrospective analysis of 18 PSC patients diagnosed between July 1984 and June 1994.
  • Exclusion of secondary causes of biliary strictures.
  • Evaluation of clinical presentation, radiological findings, associated conditions (like idiopathic ulcerative colitis), treatments, and outcomes.

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Main Results:

  • The mean age at diagnosis was 39.0 years, with a male:female ratio of 1.57:1.
  • 50% of patients had associated idiopathic ulcerative colitis.
  • Cholestatic jaundice was the most common presentation (83.3%); 27.8% developed portal hypertension.
  • All patients showed intrahepatic biliary involvement, and 66.6% had extrahepatic involvement.

Conclusions:

  • PSC does not appear to be a rare entity in India.
  • The clinical presentation and outcomes of PSC in India are comparable to those observed in Western countries.
  • Further research is needed to understand the specific epidemiology and management strategies for PSC in India.