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Biological markers and risk assessment

B D Goldstein1

  • 1Environmental and Occupational Health Sciences Institute, Piscataway, New Jersey 08855-1179, USA.

Drug Metabolism Reviews
|February 1, 1996
PubMed
Summary

Biological markers significantly improve risk assessment accuracy for workers and the public. Developing these exposure, effect, and susceptibility markers requires better biomedical understanding and regulatory adaptation.

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Area of Science:

  • Environmental Health Sciences
  • Toxicology
  • Biomedical Science

Background:

  • Current risk assessment relies heavily on mathematical models for exposure estimation.
  • Biological markers offer a more precise method for assessing exposure and predicting health outcomes.
  • Susceptibility markers can identify high-risk populations.

Purpose of the Study:

  • To highlight the potential of biological markers in advancing risk assessment.
  • To discuss the challenges and pathways for developing effective biological markers.
  • To emphasize the need for improved basic biomedical understanding.

Main Methods:

  • Review of the utility of exposure, effect, and susceptibility markers.
  • Analysis of impediments to biological marker development in risk assessment.
  • Discussion on the role of biomedical research in advancing marker science.

Main Results:

  • Biological markers provide more accurate exposure assessment than mathematical models.
  • Markers of effect enable early disease prediction and prevention.
  • Linking exposure and effect markers yields crucial dose-response data for extrapolation.
  • Susceptibility markers refine risk characterization for specific populations.

Conclusions:

  • Biological markers are essential for accurate and predictive risk assessment.
  • Overcoming regulatory reliance on mathematical models and ethical concerns is key.
  • Advancing basic biomedical understanding is the primary route to developing valuable biological markers.

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